A pioneering study conducted by experts from the Institute of Living Systems at the University of Exeter provided new insights into the creation of the human embryo.
A team of researchers discovered a unique regenerative property of cells in an early human embryo.
The first tissue that forms in the mammalian embryo is the trofectoderm, which further connects to the uterus and creates the placenta. Previous research on mice has shown that trofectoderma is made only once.
In a new study, however, the research team found that human early embryos are capable of regenerating trofectoderm. They also showed that human embryonic stem cells grown in the laboratory can similarly continue to produce trofectoderm and placenta cell types.
These findings demonstrate unexpected flexibility in human embryo development and may directly benefit from assisted conception (IVF) treatment. In addition, the possibility of creating early human placental tissue opens the door to finding the causes of infertility and miscarriage.
The study was published in a leading international journal of reviews Stem cells..
Dr Ge Guo, lead author of the study from the Institute of Living Systems, said: “We are very excited to discover that human embryonic stem cells can create any type of cell needed to create a new embryo.”
Professor Austin Smith, director of the Institute for Living Systems and co-author of the study, added: “Before Dr. Guo showed me his results, I didn’t think it should be possible. Her discovery changes our understanding of how the human embryo and what we could do with human embryonic stem cells ”
Human naive epiblast cells have unlimited vine potential, it was published in Stem cells cells.
Scientists are creating a model of an early human embryo from skin cells
Ge Guo et al. Human naive epiblast cells have unlimited vine potential, Stem cells (2021). DOI: 10.1016 / j.stem.2021.02.025
Provided by the University of Exeter
Citation: Research provides new insight into human embryo formation (2021, April 8) retrieved April 8, 2021 from https://phys.org/news/2021-04-insight-formation-human-embryo.html
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