Announcement of new publication for BIO integration magazine. In this commentary, authors Phei Er Saw and Sangyong Jon of Sun Yat-Sen University, Guangzhou, China, and the Korean Advanced Institute of Science and Technology, Daejeon, Korea, discuss how the mechanism of nanoparticle entry into tumors determines the future direction of nanomedicine development.
Enhanced permeability and retention (EPR) allows nanoparticles to passively accumulate at tumor sites through gaps between endothelial cells (interstitial gaps) in tumor-associated blood vessels that have abnormal structural integrity with pores the size of submicron to micron.
The authors consider future directions of nanomedicine development, focusing on the mechanism of nanoparticle entry into tumors, rather than on the clinical transformation itself. Designing better nanoparticles to achieve effective clinical transformation can be based on a deep understanding of the mechanism of nanoparticle entry or mode of action.