Patients with chronic coronary syndrome, diabetes may be at increased risk of CV events

April 8, 2021

1 min reading

Source / Discoveries

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Vidal-Petiot reports that she received non-financial support and personal fees from Servier outside of the job sent. Please see the study for all relevant financial disclosures by all other authors.


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Nearly 30% of patients with chronic coronary syndromes have diabetes and there is an increased risk of adverse CV outcomes, according to a study published in European Journal of Preventive Cardiology.

“Diabetes is associated with poorer outcomes, even in areas with the lowest prevalence. For example, in Europe, diabetes is associated with a 29% higher risk of a combined outcome of heart attack, stroke, or cardiovascular death. This indicates that the management of these high-risk patients with heart disease and diabetes needs to be improved. Each country must identify these patients and provide customized education and prevention programs, ” Emmanuelle Vidal-Petiot, Ph.D. MedDr.,, associate professor at the Bichat-Claude Bernard Hospital in Paris, it is stated in the press release.

Warning on the heart monitor
Source: Adobe Stock

The researchers analyzed 32,694 CLARIFY patients with chronic coronary syndromes from 45 countries. Among the cohorts, 29% had diabetes.

The researchers identified patients with more than one of the following criteria who have chronic coronary syndromes: MI, evidence of coronary stenosis greater than 50%, proven symptomatic myocardial ischemia, and previous revascularization procedure.

In a multivariable-adjusted model, researchers reported that among patients with chronic coronary syndromes, diabetes was associated with increased risks of CV death, IM, or stroke (adjusted HR = 1.28; 95% CI, 1.18–1.39), death of all causes (aHR = 1.38; 95% CI, 1.27-1.5), death from CV (aHR = 1.39; 95% CI, 1.25-1.54), MI (aHR = 1.26; 95% CI, 1.1-1.43), stroke (aHR = 1.29; 95% CI, 1.09-1.52), HF hospitalization (aHR = 1.15; 95%) CI, 1.03–1.28) and coronary revascularization (aHR = 1.14; 95% CI, 1.04–1.25).

“Obesity and lack of exercise are common risk factors for both diabetes and heart disease, and our results highlight the urgent need to improve diet and raise activity levels globally,” Vidal-Petiot said in a statement.

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