Experimental therapy in the treatment of resistant depressive dyso

Mandeep Kaur,1 Marsal Sanches2

1Department of Behavioral Medicine, Cone Health, Greensboro, NC, USA; 2UT Health Center of Excellence for Mood Disorders, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, Houston, TX, USA

Correspondence: Mandeep Kaur
General, Department of Psychiatry for Children and Adolescents, Behavioral Medicine, Cone Behavioral Health Hospital, 700 Walter Reed Drive, Greensboro, North Carolina, 27410, USA
Tel +1 (713) 540-2469
Email [email protected]

Summary: Patients who are resistant to treatment (TRD) continue to be a challenging subgroup of patients with major depressive disorder (MDD) in everyday clinical practice. As with any diagnostic condition, comprehensive assessment, exclusion of other psychiatric conditions, assessment of concomitant medical and psychiatric illnesses, and psychosocial stressors are key to proper diagnosis and subsequent management. Various management options are available for the treatment of MDD, however, about 30% of patients fail to achieve complete remission of symptoms despite multiple trials and belong to this subcategory of MDD. This article discusses other unconventional alternative medicines and alternative medicines that deserve to be explored for their effectiveness in TRD. Many of the proposed new drugs and other treatment modalities, such as deep brain stimulation, exercise, yoga, are already used for other medical and psychiatric disorders and have some evidence to suggest their potential benefits from TRD along with conventional drugs or even as monotherapy. . However, more research is needed in this direction to determine efficacy.

Keywords: major depressive disorder, treatment-resistant depression, antidepressants, pharmacology, deep brain stimulation, HPA axis, psychedelic agents


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